2 edition of Stability and drug release characteristics of multiple emulsions. found in the catalog.
Stability and drug release characteristics of multiple emulsions.
Andrew Samuel Burbage
by University of Aston in Birmingham. Department of Pharmacy in Birmingham
|Series||Ph. D thesis|
Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail. Favorable drug release mechanisms and/or rate along with in vivo fate of multiple emulsions make them a versatile carrier. thesis title of “Development of Multiple Emulsions for Drug Stability Enhancement” submitted by Nuntachai Hanpramukkun as a partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmaceutical Technology.
Oils used to prepare multiple emulsions include liquid paraffin, vegetable oils like sesame oil, olive oil, isopropyl myristate e.t.c Selection of oil phase can affect various emulsion parameters like yield, release profile, particle size & emulsion stability. Release of drug from multiple emulsions is affected by the nature of oil phase due. Effective Factors on the Stability of Oil-in-Water Emulsion Based Beverage: A Review stability of some emulsions significantly (Maia Filho et al., ). It should be noted that lipid oxidation is accelerated by reaction that take place at the surface of emulsion Size: KB.
An emulsion is a mixture of two or more liquids that are normally immiscible (unmixable or unblendable). Emulsions are part of a more general class of two-phase systems of matter called gh the terms colloid and emulsion are sometimes used interchangeably, emulsion should be used when both phases, dispersed and continuous, are liquids. In an emulsion, one liquid (the dispersed. Vasiljevic D, Parojcic J, Primorac M, Vuleta G () An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. Int J Pharm – Google Scholar.
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Multiple model emulsions are also used in the studies of the release rates, stability, rheological characteristics and other properties of emulsions [93, 94]. Multiple emulsions are emulsions where the disperse phase is itself an emulsion containing drops of another phase.
As well as improving the stability of emulsion formulations, coating emulsion droplets with nanoparticle layers is a highly effective strategy for protecting drug compounds encapsulated within the droplets and controlling their release.
There are several promising emulsion-based formulations showing high potential for drug delivery. Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail.
drug release from multiple emulsions The administration of emulsions intravenously, presence of interesting relationship between physicochemical properties and physiological response (Walster, ). The clearance of an emulsion from the blood is determined largely by its interaction with the reteculo endothelial system.
the formation of the emulsion and its long-term stability [1–3]. Emulsions may be classiﬁed according to the nature of the emulsiﬁer or the structure of the system.
This is illustrated in Table Nature of the Emulsiﬁer ThesimplesttypeisionssuchasOH− that can be speciﬁcally adsorbed on the emulsion droplet thus producing a File Size: KB.
Possible mechanism of drug release from multiple emulsions In multiple emulsions, the drug is released from internal to external phase through the oily layer by different mechanism. The release rates are affected by the various factors such as droplet size, pH, phase volume and viscosity various Mechanisms are:File Size: KB.
The measurement of both the droplet size and size distribution of emulsions is a critical metric. A variety of sizing techniques are available but, from Figure 1, it is obvious that image analysis (for regular emulsions) should be a prime candidate.
Emulsion Stability Testing. Stability testing is an integral part of emulsion development work. Other favorite cosmetic characteristics of multiple emulsions include occlusivity (in O/W/O emulsions), esthetics and consumer acceptance.
Vitamin C (ascorbic acid) has been widely used in. Structure and Rheology of Stable Multiple Emulsions 29 P. Perrin, F. Prigent, and P. Hébraud 3.
Visualization of Stability and Transport in Double Emulsions 45 Louise Braud Lawson and Kyriakos Papadopoulos 4. Effect of an Oil-Insoluble Solute on the Stability of Multiple Water-Oil-Water Emulsions 67 Mouhcine Kanouni and Henri Rosano 5.
Structure and Rheology of Stable Multiple Emulsions by P. Perrin, F. Prigent, and Ph. H’ebraud. Visualization of Stability and Transport in Double Emulsions by Louise Braud Lawson and Kyriakos Papadopoulos.
Effect of an Oil-insoluble Solute on the Stability of Multiple Water-Oil-Water Emulsions by Mouhcine Kanouni and Henri Rosano. Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail.
Favorable drug release mechanisms and/or rate along with in vivo fate of multiple emulsions make them a versatile by: achieving stable multiple emulsions. Valsartan was selected as a model drug to study the potential of multiple emulsion to improve bioavailability with the hypothesis that improvement of drug release profile will reflect the enhancement of bioavailability of the drug.
The objective of this study was to prepare multiple emulsion ofFile Size: KB. Emulsions and Emulsion Stability, Second Edition provides comprehensive coverage of both theoretical and practical aspects of emulsions.
The book presents fundamental concepts and processes in emulsified systems, such as flocculation, coalescence, stability, precipitation, deposition, and the evolution of droplet size : Hardcover. The purpose of this review article is to provide a critical overview of the most important properties of emulsions that are of interest to the food industry, the type of analytical techniques that are available to measure these properties, and the experimental protocols that have been developed to characterize the stability of food by: Description: Emulsions and Emulsion Stability, Second Edition provides comprehensive coverage of both theoretical and practical aspects of emulsions.
The book presents fundamental concepts and processes in emulsified systems, such as flocculation, coalescence, stability, precipitation, deposition, and the evolution of droplet size distribution.
Multiple emulsions 1. MULTIPLE EMULSIONS BBYY, VV. RREEKKHHAA RRMMAACCYY PPHHAARRMMAACCEEUUTTIICCSS 2. IINNTTRROODDUUCCTTIIOONN Emulsions may be described as heterogenous systems, where one immiscible liquid is dispersed in another in the form of droplets and stabilized by a third component.
Written by some of the top scientists within their respective fields, this book covers such topics as emulsions, nano-emulsions, nano-dispersions and novel techniques for their investigation.
It also considers the fundamental approach in areas such as controlled release, drug delivery and various applications of nanotechnology.4/5(1). The stability against coalescence of vegetable oil-in-water “food grade” emulsions in the presence of both surfactant and colloidal particles (hydrophilic silica) has been studied and compared to the stability of systems where only the surfactant or the colloidal particles act as the emulsifier.
INTRODUCTION. Emulsions are the most common forms of skin care products (Epstein, ).By definition, an emulsion is a heterogeneous system of two or more immiscible liquids in which one is dispersed in the other (Epstein, ).Emulsions used in personal care application, both oil-in-water (O/W) and water-in-oil (W/O) type, need to satisfy a number of criteria, such as having the right.
The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high loading of multiple drugs, tunable drug release profile, and good serum stability.
Several drugs do not have adequate physiochemical characteristics such as high lipid solubility, low molecular size, and positive charge, to traverse Cited by: 4. Multiple emulsions - Novel development in emulsion technology.
Complex type of multiple system. Also called, Emulsion of emulsion. Double or triple emulsion. 4 Internal oil droplet External oil medium Intermediate water phase 5. Types of multiple emulsions - 1. w/o/w system – • Oil droplet surrounded by aqueous phase.Summary Emulsions and Emulsion Stability, Second Edition provides comprehensive coverage of both theoretical and practical aspects of emulsions.
The book presents fundamental concepts and processes in emulsified systems, such as flocculation, coalescence, stability, precipitation, deposition, and the evolution of droplet size distribution.release profile, particle size and emulsion stability.
The release of drug from multiple emulsion is affected by the nature of the oil phase due to the difference in partition coefficient. ASE The selection of surfactants depends upon the use of the multiple emulsion. .